Medicinal Chemistry

  • Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification
    G. Karpel-Massler, R. E. Kast, M. D. Siegelin, A. Dwucet, E. Schneider, M.-A. Westhoff, C. R. Wirtz, X. Y. Chen, M.-E. Halatsch, C. Bolm, Neurochem. Res. 2017, 42, 3382–3389.

  • Sulfoximines as ATR inhibitors: Analogs of VE-821
    C. M. M. Hendriks, J. Hartkamp, S. Wiezorek, A.-D. Steinkamp, G. Rossetti, B. Lüscher, C. Bolm, Bioorg. Med. Chem. Lett. 2017, 27, 2659–2662.

  • Sulfoximines from a Medicinal Chemist’s Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery
    M. Frings, C. Bolm, A. Blum, C. Gnamm, Eur. J. Med. Chem. 2017, 126, 225–245.

  • Synthesis of a sulfonimidamide-based analog of Tasisulam and its biological evaluation in the melanoma cell lines SKMel23 and A375
    A.-D. Steinkamp, L. Schmitt, X. Chen, K. Fietkau, R. Heise, J. Baron, C. Bolm, Skin Pharmacol. Physiol. 2016, 29, 281–290.

  • Synthesis of N-Cyano-substituted Sulfilimine and Sulfoximine Derivatives of S0859 and their Biological Evaluation as Sodium Bicarbonate Co-transport Inhibitors
    A.-D. Steinkamp, N. Seling, S. Lee, E. Boedtkjer, C. Bolm, MedChemCommun 2015, 6, 2163–2169.

  • Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities
    C. M. M. Hendriks, T. M. Penning, T. Zang, D. Wiemuth, S. Gründer, I. A. Sanhueza, F. Schoenebeck, C. Bolm, Bioorg. Med. Chem. Lett. 2015, 25, 4437–4440.

  • Methionine and Buthionine Sulfoximine: Syntheses under Mild and Safe Imidation/Oxidation Conditions
    L. Buglioni, V. Bizet, C. Bolm, Adv. Synth. Catal. 2014, 356, 2209–2213.

  • N-Cyano Sulfoximines: COX Inhibition, anti-Cancer Activity, Cellular Toxicity, and Mutagenicity 
    S. J. Park, H. Baars, H. Buschmann, J. M. Baron, P. M. Amann, K. Czaja, H. Hollert, K. Bluhm, R. Redelstein, C. Bolm, ChemMedChem. 2013, 8, 217–220.

  • Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins
    X. Y. Chen, S. J. Park, H. Buschmann, M. De Rosa, C. Bolm, Bioorg. Med. Chem. Lett. 2012, 22, 4307–4309.

  • Bioactive Sulfoximines: Syntheses and properties of Vioxx® analogs
    S. J. Park, H. Buschmann, C. Bolm, Bioorg. Med. Chem. Lett. 2011, 21, 4888–4890.